Post by Planet Asia on Dec 18, 2005 5:42:22 GMT -5
"A particular case in question is the origin of haplogroup M1, which is mainly found in Northeast Africa and the Near East (Quintana-Murci et al. 1999). Due to the
fact that M1 bears variant nucleotides, for example, at site 16311 in common with haplogroup M4, at 16129 with M5, and at 16249 with haplogroup M34, it has been
proposed that M1 might have some affinity with Indian M haplogroups (Roychoudhury et al. 2001). This inference, however, could not receive support from
our complete sequencing information. Indeed, the reconstructed ancestral motifs of all Indian M haplogroups turned out to be devoid of those variations that characterized M1, i.e., 6446, 6680, 12403, and 14110 (Maca-Meyer et al. 2001; Herrnstadt et al.
2002). Therefore, those common mutations in the control region rather reflect random parallel mutations. There is no evidence whatsoever that M1 originated in India."
The Dazzling Array of Basal Branches in the mtDNA Macrohaplogroup M from India as Inferred from Complete Genomes
fact that M1 bears variant nucleotides, for example, at site 16311 in common with haplogroup M4, at 16129 with M5, and at 16249 with haplogroup M34, it has been
proposed that M1 might have some affinity with Indian M haplogroups (Roychoudhury et al. 2001). This inference, however, could not receive support from
our complete sequencing information. Indeed, the reconstructed ancestral motifs of all Indian M haplogroups turned out to be devoid of those variations that characterized M1, i.e., 6446, 6680, 12403, and 14110 (Maca-Meyer et al. 2001; Herrnstadt et al.
2002). Therefore, those common mutations in the control region rather reflect random parallel mutations. There is no evidence whatsoever that M1 originated in India."
The Dazzling Array of Basal Branches in the mtDNA Macrohaplogroup M from India as Inferred from Complete Genomes
