Mexican genetic results Jan 10, 2006 15:16:20 GMT -5
Post by vgambler33 on Jan 10, 2006 15:16:20 GMT -5
Genetic admixture in three Mexican Mestizo populations based on D1S80 and HLA-DQA1 loci.
Cerda-Flores RM, Villalobos-Torres MC, Barrera-Saldana HA, Cortes-Prieto LM, Barajas LO, Rivas F, Carracedo A, Zhong Y, Barton SA, Chakraborty R.
Departamento de Genetica de Poblaciones, Centro de Investigacion Biomedica del Noreste (CIBIN), Instituto Mexicano del Seguro Social, Monterrey, Nuevo Leon, Mexico.
This study compares genetic polymorphisms at the D1S80 and HLA-DQA1 loci in three Mexican Mestizo populations from three large states (Nuevo Leon, Jalisco, and the Federal District). Allele frequency distributions are relatively homogenous in the three samples; only the Federal District population shows minor differences of the HLA-DQA1 allele frequencies compared with the other two. In terms of genetic composition, these Mestizo populations show evidence of admixture with predominantly Spanish-European (50-60%) and Amerindian (37-49%) contributions; the African contribution (1-3%) is minor. Together with the observation that in Nuevo Leon, the admixture estimates based on D1S80 and HLA-DQA1, are virtually the same as those reported earlier from blood group loci, suggests that DNA markers, such as D1S80 and HLA-DQA1 are useful for examining genetic homogeneity/heterogeneity across Mestizo populations of Mexico. The inverse relationship of the proportion of gene diversity due to population differences (Gst) to within population gene diversity (Hs) is also consistent with theoretical predictions, supporting the use of these markers for population genetics studies.
PMID: 11891937 [PubMed - indexed for MEDLINE]